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Epigenetic Changes May Pass Avoidance Behavior Down Multiple Generations

Science classes teach that an
individual’s traits are mainly encoded in their genetic sequence—or DNA—which
then gets transcribed into RNA
that subsequently gets translated into the proteins that carry out cellular
functions. But while this is generally true for the majority of traits, it does
not account for how all characteristics are passed down across generations. It turns
out, epigenetics
may play a large role in how traits are inherited.

Researchers at Princeton’s
Department of Molecular Biology and the Lewis-Sigler Institute for Integrative
Genomics became intrigued by how the nematode C. elegans seemed
to pass avoidance behavior towards specific pathogens down across a finite
set of generations before the trait would reset. Not all pathogens triggered
such a response, and so they focused on studying the one they knew did: Pseudomonas
aeruginosa
.  After encountering the pathogen and learning to avoid
it, C. elegans‘ avoidance is transferred across four generations
before completely resetting, so that any further resistance must be reacquired
via exposure.

A simple experiment in nematodes spoke volumes on
epigenetics.

C. elegans were exposed to one of
two common pathogens—Pseudomonas aeruginosa or Serratia
marcescens
—with both of these pathogens triggering avoidance behaviors upon
nematode exposure. However, only Pseudomonas aeruginosa saw
inherited avoidance across generations, suggesting that this is a
pathogen-specific mechanism and not a universal response. Comparison of male
and female germlines revealed that both were capable of transmitting the
avoidance.

Skeptics might argue that perhaps
the developing progeny might have been exposed to the pathogen before being
born. But the avoidance behavior did not simply last across mother and child;
it endured over four total generations, implicating some other process for
transmission.

Analysis of gene transcription profiles of wild-type and
exposed mothers and progeny showed a large number of differences in immunity,
metabolism, and regulation of gene expression—not just posttranslational modifications
but also epigenetics. Changes in complex histone
modifications
—which alter how DNA is wound around histone proteins or
unwound and “exposed” for translation into RNA—were detected
alongside changes in the small RNA regulators needed to generate the desired
proteins. Specifically, the PRG-1/Piwi 22G siRNA
pathway was found to direct the epigenetic modifications that conferred
transgenerational inheritance of pathogenic avoidance. By modifying
the chromatin
, this pathway affects how “accessible” the genetic
material is for the cell’s translational and transcriptional processes.

Epigenetic modifications factor in the critical element
of timescale.

Epigenetic changes are just one part
of the nematode’s response to Pseudomonas aeruginosa exposure,
accompanied by an immediate upsurge in immune function to help stave off any
potential illness and even death. Avoidance of this particular pathogen has
been shown to directly promote C. elegans survival, and so
conferring this avoidance across multiple generations supports future progeny
that in turn can help keep the species alive.

Knowing how important survival is,
then, why is this avoidance not hard-wired into C. elegans?

The answer lies in looking at
the Pseudmonas genus. Although Pseudomonas aeruginosa can
be a destructive pathogen for C. elegans, some Pseudomonas are
actually a source of nutrition; in fact, at low temperatures, even Pseudomonas
aeruginosa can be a food source—it’s only at higher temperatures that it
becomes truly dangerous. It has also been demonstrated that C. elegans trained
to avoid pathogenic Pseudomonas also avoid the less pathogenic
ones. Consider how detrimental it would be if C. elegans were
to have an entire category of potential food sources immediately ruled out,
particularly if they encounter a hostile or otherwise stressed environment. 

Flexibility and adaptation pave the way of the future.

Transferring this avoidance across a few generations allows for C. elegans to survive, while also remaining flexible and adaptive to conditions and evolving needs over time. This sort of long-term flexibility in adaptation in turn promotes survival of the species. Although this research was a major step in the right direction, further study of such epigenetic survival machinery needs to be conducted to further characterizes the processes at play not just in a relatively simple model organism like C. elegans, but ultimately within the complex systems of more complex organisms such as humans.

Source: Moore,
Rebecca S, et al. “Piwi/PRG-1
Argonaute and TGF-β
Mediate Transgenerational Learned Pathogenic Avoidance.”
Cell, U.S.
National Library of Medicine, 13 June 2019

Reference: Caitlin Sedwick “Danger avoidance can be genetically encoded for four generations
UAB News. 6 June 2019. Web.

The article Epigenetic Changes May Pass Avoidance Behavior Down Multiple Generations appeared first on What is Epigenetics?.

Updated: September 10, 2019 — 7:15 pm
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